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Neuro

Neuro biomarkers and tools (MRI)

Through participation in large scale European projects, public private collaborations and bilateral research agreements with leading research organisations, we can provide services in a wide range of quantitative analysis problems in the neuro domain, supporting population and clinical research in e.g. dementia and other neurological diseases.

brain_tissueslobes WMH_FLAIR


Examples of quantitative imaging biomarkers and tools include:

  • Quantification of brain tissue and CSF volumes
  • Quantification of brain lobe volumes
  • Quantification of white matter hyperintensities
  • Microbleed detection
  • Detection of enlarged Virchow Robin spaces
  • Arterial Spin Labeling (ASL-MRI) based cerebral blood flow measurements
  • Analysis of DW-MRI measures
  • Automatic tract segmentation in DW-MRI
  • Structural connectivity mapping (DW-MRI)
  • Functional connectivity mapping ((resting state) fMRI)
  • Segmentation of neurostructures
  • Shape analysis of neurostructures

 

hippocampus

Scientific references

Many of these biomarkers have been documented in peer reviewed papers, thoroughly validated, and applied in the context of population and clinical imaging studies.

  • W. Niessen, MR brain image analysis in dementia: From quantitative imaging biomarkers to ageing brain models and imaging genetics, Medical Image Analysis, 2016
  • H.A. Vrooman, et al., Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification, NeuroImage, 2007
  • R. de Boer, et al., White matter lesion extension to automatic brain tissue segmentation on MRI, NeuroImage, 2009
  • R.M.E Steketee, et al., Quantitative functional arterial spin labeling (fASL) MRI - sensitivity and reproducibility of regional CBF changes using pseudo-continuous ASL product sequences, PLoS ONE, 2015
  • M. de Groot, et al., White Matter Degeneration with Aging: Longitudinal Diffusion MR Imaging Analysis, Radiology, 2016
  • M. de Groot, et al., Changes in normal-appearing white matter precede development of white matter lesions, Stroke, 2013
  • M. de Groot, et al., Tract-specific white matter degeneration in aging. The Rotterdam Study, Alzheimer's & Dementia, 2015
  • R. de Boer, et al., Statistical analysis of minimum cost path based structural brain connectivity, NeuroImage, 2011
  • H.C. Achterberg, et al., Hippocampal shape is predictive for the development of dementia in a normal, elderly population, Human Brain Mapping, 2014
Contact for more information:

services@quantib.com
or call us at
(+31) 108 41 17 49